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Cytotoxicity after 5-FC prodrug treatment in uninfected (naïve), RRV-GFP-infected, and Toca 511-infected A549 (A) and Ex-3LL cells (B) in vitro. Cell viability was measured by MTS assay after incubation with different concentrations of 5-FC, as shown, for 4 days. Data are reported as the percentage (mean ± SD) of viable cells, normalized to uninfected control cells without prodrug.
