Figure 7.

Systemic biodistribution of Toca 511 in orthotopic human lung cancer model. Genomic DNA was extracted from various tissues after Toca 511/5-FC-treatment in pleural dissemination model of A549 human lung cancer in athymic nude mice, as described in Figure 6B (n = 3 per tissue). Integrated RRV sequences were quantitated by qPCR based on reference curve values and expressed as vector copy number per 100 cell genome equivalents of DNA. The logarithmic graph was shown in Supplementary Figure S3.