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Accumulation of melanomic EVs in the liver and lungs of immunodeficient mice. (A) Inoculation of PBS served as control without EVs. (B) Large EVs derived from HSteCs, (C) HEK293, or (D–F) UM cell lines (Mµ2, Mµ2F, TJU-UM001) were labeled with Exoglow before being inoculated in the retro-orbital sinus of NCG mice (n = 4/condition). Fluorescence of the liver, lungs, kidneys, heart, and spleen was analyzed with the IVIS after 24 h.
