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. 2022 Nov 29;11(23):3828. doi: 10.3390/cells11233828

Figure 7.

Figure 7

UM-derived EVs increase collagen gel contraction by stellate cells. (A) Representative images of collagen gels (1 mg/mL) without embedded HSteCs, with embedded HSteCs not treated with EVs, and with embedded HSteCs treated during 24 h with large EVs derived from NCMs or metastatic UM cell line TJU-UM001 taken with a stereomicroscope. (B) Corresponding quantification of the collagen gel area (in percentage) for each condition during 48 h. Error bars indicate ±SEM (n = 3); ** p < 0.01 and **** p < 0.0001 (two-way ANOVA with Sidak’s multiple comparisons test).