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. 2022 Nov 22;23(23):14516. doi: 10.3390/ijms232314516

Figure 10.

Figure 10

YAP1 inhibition with verteporfin prevents hypoxia-mediated PH and pulmonary vascular remodeling in mice. (A) Representative record of right ventricular pressure (RVP); (B) changes in right ventricular systolic pressure (RVSP); (C) changes in right ventricular hypertrophy (RV/(LV + S); (D) changes in ratios of wall area to total vessel area of pulmonary arteries less than 50 μm in diameter in the lung sections of control and verteporfin-treated groups after normoxia or hypoxia exposure; (E) changes in ratios of wall area to total vessel area of pulmonary arteries less than 50–100 μm in diameter in the lung sections of control and verteporfin-treated groups after normoxia or hypoxia exposure; (F) representative pulmonary artery images in the lung sections of control and verteporfin-treated groups after normoxia or hypoxia exposure. Bar size: 10 μm. Results are expressed as mean ± SEM; number of mice in each group (n = 5–6) is shown in (B,C). *** p < 0.001 versus normoxia without verteporfin group; # p < 0.05; ## p < 0.01; ### p < 0.001 versus hypoxia without verteporfin group.