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. 2022 Dec 4;23(23):15296. doi: 10.3390/ijms232315296

Figure 2.

Figure 2

The glutaminolysis pathway and its inhibitors. Glutamine is the most prevalent amino acid in the blood and serves as a fuel source for the biosynthesis of fatty acids, nucleotides, and antioxidants in CSCs. MYC has the ability to raise the expression levels of the glutamine transporter ASCT2 as well as glutaminase. The glutaminolysis inhibitors include glutamine analogues such as DON, JHU-083, and acivicin azaserine, as well as glutaminase inhibitors such as CB-839, BPTES, compound 968, and C9.22. These inhibitors have the ability to prevent CSCs from engaging in metabolic compensation and from exhibiting aggressive phenotypes.