Table 3.
PC | Aß40 | S100b | YKL-40 | GFAP | sTREM2 | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Estimate | p | adjusted p | Estimate | p | adjusted p | Estimate | p | adjusted p | Estimate | p | adjusted p | Estimate | p | adjusted p | |
PC8 | −1.0386 | 8.19E-05 | 4.91E-04 | −0.6541 | 9.50E-02 | 5.70E-01 | −0.6743 | 2.22E-02 | 1.33E-01 | −0.5209 | 5.38E-02 | 3.23E-01 | −0.4676 | 1.10E-01 | 6.61E-01 |
PC13 | −0.7386 | 1.20E-04 | 7.18E-04 | −0.556 | 5.20E-02 | 3.12E-01 | −0.6452 | 2.68E-03 | 1.61E-02 | −0.5767 | 3.36E-03 | 2.02E-02 | −0.7602 | 3.44E-04 | 2.06E-03 |
PC16 | −0.7849 | 2.10E-06 | 1.26E-05 | −0.5102 | 3.98E-02 | 2.39E-01 | −0.4179 | 2.55E-02 | 1.53E-01 | −0.4597 | 7.12E-03 | 4.27E-02 | −0.4600 | 1.30E-02 | 7.80E-02 |
PC20 | −0.3539 | 7.43E-03 | 4.46E-02 | −0.2341 | 2.30E-01 | 1.00E+00 | −0.3198 | 2.93E-02 | 1.76E-01 | −0.0725 | 5.91E-01 | 1.00E+00 | −0.1122 | 4.42E-01 | 1.00E+00 |
PC22 | −1.0232 | 6.68E-16 | 4.01E-15 | −0.568 | 3.60E-03 | 2.16E-02 | −0.9452 | 4.24E-11 | 2.55E-10 | −0.4465 | 8.87E-04 | 5.32E-03 | −0.7373 | 2.98E-07 | 1.79E-06 |
PC29 | −0.2421 | 2.08E-02 | 1.25E-01 | −0.2432 | 1.16E-01 | 6.95E-01 | −0.3454 | 2.93E-03 | 1.76E-02 | −0.3116 | 3.36E-03 | 2.02E-02 | −0.2827 | 1.42E-02 | 8.53E-02 |
PC | IL-6 | NfL | Neurogranin | α-synuclein | |||||||||||
Estimate | p | adjusted p | Estimate | p | adjusted p | Estimate | p | adjusted p | Estimate | p | adjusted p | ||||
PC8 | −0.0005 | 9.98E-01 | 1.00E+00 | −0.2898 | 2.30E-01 | 1.00E+00 | −0.6745 | 2.91E-03 | 1.74E-02 | −0.5632 | 4.30E-03 | 2.58E-02 | |||
PC13 | 0.2389 | 8.89E-02 | 5.34E-01 | −0.4175 | 1.77E-02 | 1.06E-01 | −0.5589 | 7.19E-04 | 4.31E-03 | −0.5954 | 3.19E-05 | 1.92E-04 | |||
PC16 | 0.2260 | 6.35E-02 | 3.81E-01 | −0.2815 | 6.57E-02 | 3.94E-01 | −0.5824 | 4.55E-05 | 2.73E-04 | −0.4340 | 5.00E-04 | 3.00E-03 | |||
PC20 | −0.0766 | 4.26E-01 | 1.00E+00 | −0.0897 | 4.56E-01 | 1.00E+00 | −0.3721 | 9.44E-04 | 5.66E-03 | −0.2101 | 3.27E-02 | 1.96E-01 | |||
PC22 | −0.1110 | 2.50E-01 | 1.00E+00 | −0.6176 | 1.87E-07 | 1.12E-06 | −0.9353 | 4.32E-18 | 2.59E-17 | −0.6923 | 4.03E-13 | 2.42E-12 | |||
PC29 | −0.0370 | 6.28E-01 | 1.00E+00 | −0.1841 | 5.31E-02 | 3.19E-01 | −0.2736 | 2.21E-03 | 1.33E-02 | −0.1716 | 2.79E-02 | 1.68E-01 | |||
PC | MRI TBV | MRI HV | PiB DVR | ||||||||||||
Estimate | p | adjusted p | Estimate | p | adjusted p | Estimate | p | adjusted p | |||||||
PC8 | −4.2023 | 2.00E-02 | 1.20E-01 | 0.2984 | 7.15E-01 | 1.00E+00 | 0.8142 | 3.32E-01 | 1.00E+00 | ||||||
PC13 | −1.1585 | 3.88E-01 | 1.00E+00 | 0.3675 | 5.44E-01 | 1.00E+00 | 0.9058 | 8.70E-02 | 5.22E-01 | ||||||
PC16 | −1.1467 | 3.24E-01 | 1.00E+00 | −0.8184 | 1.19E-01 | 7.11E-01 | 0.0664 | 9.02E-01 | 1.00E+00 | ||||||
PC20 | −1.3188 | 1.56E-01 | 9.35E-01 | −0.3608 | 3.90E-01 | 1.00E+00 | −0.0315 | 9.40E-01 | 1.00E+00 | ||||||
PC22 | −0.0783 | 9.33E-01 | 1.00E+00 | −0.8996 | 3.28E-02 | 1.97E-01 | 0.6842 | 1.52E-01 | 9.10E-01 | ||||||
PC29 | −1.9791 | 6.67E-03 | 4.00E-02 | −0.1509 | 6.48E-01 | 1.00E+00 | 0.3121 | 3.64E-01 | 1.00E+00 |
The adjusted p values were calculated based on the Bonferroni adjustment for 6 PCs.