Skip to main content
. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: Neurobiol Aging. 2022 May 3;117:12–23. doi: 10.1016/j.neurobiolaging.2022.04.009

Table 3.

Results of the association tests between 6 significant PCs and NTK CSF biomarkers and imaging markers.

PC Aß40 S100b YKL-40 GFAP sTREM2
Estimate p adjusted p Estimate p adjusted p Estimate p adjusted p Estimate p adjusted p Estimate p adjusted p
PC8 −1.0386 8.19E-05 4.91E-04 −0.6541 9.50E-02 5.70E-01 −0.6743 2.22E-02 1.33E-01 −0.5209 5.38E-02 3.23E-01 −0.4676 1.10E-01 6.61E-01
PC13 −0.7386 1.20E-04 7.18E-04 −0.556 5.20E-02 3.12E-01 −0.6452 2.68E-03 1.61E-02 −0.5767 3.36E-03 2.02E-02 −0.7602 3.44E-04 2.06E-03
PC16 −0.7849 2.10E-06 1.26E-05 −0.5102 3.98E-02 2.39E-01 −0.4179 2.55E-02 1.53E-01 −0.4597 7.12E-03 4.27E-02 −0.4600 1.30E-02 7.80E-02
PC20 −0.3539 7.43E-03 4.46E-02 −0.2341 2.30E-01 1.00E+00 −0.3198 2.93E-02 1.76E-01 −0.0725 5.91E-01 1.00E+00 −0.1122 4.42E-01 1.00E+00
PC22 −1.0232 6.68E-16 4.01E-15 −0.568 3.60E-03 2.16E-02 −0.9452 4.24E-11 2.55E-10 −0.4465 8.87E-04 5.32E-03 −0.7373 2.98E-07 1.79E-06
PC29 −0.2421 2.08E-02 1.25E-01 −0.2432 1.16E-01 6.95E-01 −0.3454 2.93E-03 1.76E-02 −0.3116 3.36E-03 2.02E-02 −0.2827 1.42E-02 8.53E-02
PC IL-6 NfL Neurogranin α-synuclein
Estimate p adjusted p Estimate p adjusted p Estimate p adjusted p Estimate p adjusted p
PC8 −0.0005 9.98E-01 1.00E+00 −0.2898 2.30E-01 1.00E+00 −0.6745 2.91E-03 1.74E-02 −0.5632 4.30E-03 2.58E-02
PC13 0.2389 8.89E-02 5.34E-01 −0.4175 1.77E-02 1.06E-01 −0.5589 7.19E-04 4.31E-03 −0.5954 3.19E-05 1.92E-04
PC16 0.2260 6.35E-02 3.81E-01 −0.2815 6.57E-02 3.94E-01 −0.5824 4.55E-05 2.73E-04 −0.4340 5.00E-04 3.00E-03
PC20 −0.0766 4.26E-01 1.00E+00 −0.0897 4.56E-01 1.00E+00 −0.3721 9.44E-04 5.66E-03 −0.2101 3.27E-02 1.96E-01
PC22 −0.1110 2.50E-01 1.00E+00 −0.6176 1.87E-07 1.12E-06 −0.9353 4.32E-18 2.59E-17 −0.6923 4.03E-13 2.42E-12
PC29 −0.0370 6.28E-01 1.00E+00 −0.1841 5.31E-02 3.19E-01 −0.2736 2.21E-03 1.33E-02 −0.1716 2.79E-02 1.68E-01
PC MRI TBV MRI HV PiB DVR
Estimate p adjusted p Estimate p adjusted p Estimate p adjusted p
PC8 −4.2023 2.00E-02 1.20E-01 0.2984 7.15E-01 1.00E+00 0.8142 3.32E-01 1.00E+00
PC13 −1.1585 3.88E-01 1.00E+00 0.3675 5.44E-01 1.00E+00 0.9058 8.70E-02 5.22E-01
PC16 −1.1467 3.24E-01 1.00E+00 −0.8184 1.19E-01 7.11E-01 0.0664 9.02E-01 1.00E+00
PC20 −1.3188 1.56E-01 9.35E-01 −0.3608 3.90E-01 1.00E+00 −0.0315 9.40E-01 1.00E+00
PC22 −0.0783 9.33E-01 1.00E+00 −0.8996 3.28E-02 1.97E-01 0.6842 1.52E-01 9.10E-01
PC29 −1.9791 6.67E-03 4.00E-02 −0.1509 6.48E-01 1.00E+00 0.3121 3.64E-01 1.00E+00

The adjusted p values were calculated based on the Bonferroni adjustment for 6 PCs.