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. 2022 Nov 26;14(23):5840. doi: 10.3390/cancers14235840

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The impact of sialylation on immune cell functions. Siglec: sialic acid-binding immunoglobulin-like lectin; MICA: MHC class I–related chain A; NKGD2: natural-killer group 2, member D; IgG: immunoglobulin G; ADCC: antibody-dependent cell-mediated cytotoxicity; SHP: Src homology region 2 domain-containing phosphatase; MHC: major histocompatibility complex; TCR: T cell receptor; PD-1: programmed death-1; PD-L1: programmed death-ligand 1; ZAP70: zeta chain of T cell receptor associated protein kinase 70; NFAT: nuclear factor of activated T-cells.