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. 2022 Dec 10;8(12):e12295. doi: 10.1016/j.heliyon.2022.e12295

Table 2.

Factors associated with adverse skin reactions among the hand sanitizer users.

Factors Adverse skin reactions (n = 515, 41.9%)a Bivariate analysis
Multivariate analysis
Crude OR (95% CI) p-valueb Adjusted OR (95% CI) p-valueb
Age, years
 ≤21 110 (21.36%) Reference <0.001
Reference 0.004
 22-26 159 (30.87%) 2.14 (1.56─2.93) 0.63 (0.36─1.1)
 27-34 135 (26.21%) 2.42 (1.74─3.38) 0.48 (0.25─0.89)
 ≥35
111
(21.55%)
1.29
(0.93─1.78)
0.41
(0.23─0.75)
Gender
 Male 287 (55.73%) Reference 0.508
Reference
 Female 228 (44.27%) 1.08 (0.86─1.36) 1.92 (1.37─2.7) <0.001

Educational Status
 Illiterate 7 (1.36%) Reference 0.168
Reference 0.384
 Primary 31 (6.02%) 1.69 (0.62─4.6) 1.21 (0.4─3.68)
 Secondary 43 (8.35%) 1.35 (0.51─3.53) 0.85 (0.27─2.64)
 Higher Secondary 73 (14.17%) 1.26 (0.5─3.21) 0.60 (0.19─1.89)
 Graduate 288 (55.92%) 1.89 (0.77─4.65) 0.71 (0.23─2.22)
 Post-graduate 73 (14.17%) 1.62 (0.63─4.14) 0.89 (0.28─2.82)

Marital Status
 Unmarried 241 (46.89%) Reference <0.001
Reference 0.246
 Married 266 (51.75%) 1.60 (1.27─2.1) 1.24 (0.86─1.77)
 Widow∖Divorced∖Separated 7 (1.36%) 0.80 (0.32─1.99) 0.59 (0.19─1.83)

Religion
 Islam 387 (75.15%) Reference 0.006
Reference 0.020
 Hindu 99 (19.22%) 0.68 (0.51─0.89) 1.03 (0.69─1.53)
 Buddhism 24 (4.66%) 1.84 (0.97─3.47) 1.71 (0.76─3.88)
 Other 5 (0.97%) 1.63 (0.43─6.1) 14.5 (1.52─139.86)

Occupation
 NHCW 252 (30.51%) Reference <0.001
Reference <0.001
 HCW 263 (65.10%) 4.25 (3.3─5.47) 3.50 (2.23─5.49)

Work hour (hours/week)
 <8 85.00 (19.45%) Reference <0.001
Reference <0.001
 8 to 16 64.00 (14.65%) 1.60 (1.5─2.45) 1.62 (1─2.64)
 16 to 24 17.00 (3.89%) 1.43 (0.72─2.81) 1.30 (0.61─2.75)
 24 to 32 37.00 (8.47%) 2.16 (1.26─3.7) 1.88 (1.03─3.43)
 32 to 48 66.00 (15.1%) 1.50 (0.99─2.27) 1.24 (0.75─2.04)
 48 to 56 97 (22.2%) 1.87 (1.28─2.74) 2.38 (1.46─3.87)
 >56 71 (16.25%) 5.07 (3.3─8.49) 2.51 (1.34─4.7)

Hand hygiene products
 Alcohol based sanitizer 427 (82.91%) 2.06 (1.56─2.72) <0.001 1.40 (0.93─2.1) 0.107
 Soap water 365 (70.87%) 1.13 (0.88─1.45) 0.325 0.97 (0.69─1.37) 0.88
 Detergent/Savlon solution/bleaching powder solution 8 (1.55%) 1.59 (0.57─4.42) 0.371 1.21 (0.33─4.43) 0.76

Daily use frequency (times/day)
 1 to 4 103 (20%) Reference <0.001 Reference 0.001
 5 to 10 205 (39.81%) 2.48 (1.84─3.34) 1.98 (1.33─2.95)
 11 to 15 108 (20.97%) 2.61 (1.84─3.71) 1.96 (1.22─3.15)
 16 to 20 44 (8.54%) 3.52 (2.12─5.86) 1.84 (0.97─3.5)
 >20 55 (10.68%) 2.27 (1.48─3.49) 0.92 (0.53─1.61)
H/O COVID-19 infection 232 (45.05%) 3.04 (2.37─3.9) <0.001 1.83 (1.29─2.61) 0.001

Vaccination Status
 Not vaccinated 114 (22.14%) Reference <0.001 Reference 0.590
 Received first dose 55 (10.68%) 1.42 (0.94─2.15) 1.16 (0.68─1.99)
 Fully vaccinated 346 (67.18%) 1.75 (1.34─2.29) 0.98 (0.64─1.51)
a

Data are presented as n (%).

b

Significant p-values (<0.05) are in boldOR, odds ratio; CI, confidence interval; NHCW, non-healthcare workers; HCW, healthcare workers.