Ub	Ubiquitin
Ub-G76	C-terminal glycine residue of the Ub
M1	Methionine-1
Oct4	Octamer-binding transcription factor-4
E1	Ub activating enzyme
E2	Ub binding enzyme
E3	Ub ligase
C	Cysteine
RING	Really interesting new gene
HECT	Homologous to E6-AP COOH terminus
RBR	RING between RING
Nedd4	Neuronal precursor cell-expressed developmentally downregulated 4
HERC	HECT and RLD-containing
RLD	RCC1-like domains
UPS	Ubiquitin proteasome system
Ube2c	Ubiquitin-conjugating enzyme 2C
Gp78	Glycoprotein 78
ERAD	Endoplasmic reticulum-associated degradation
MDM2/HDM2	Mouse double minute 2/human homolog of mouse double minute 2
TP53	Tumor protein p53
COP1	Constitutive photomorphogenesis protein 1
Pirh2	P53-induced protein with a RING-H2 domain
CHIP	Co-chaperone carboxyl terminus Hsp70/90-interacting protein
Skp2	S-phase kinase-associated protein 2
Cul1	Cullin 1
Rbx1	Ring box 1
Skp1	S-phase kinase-associated protein 1
SCFSkp2 complex	The RING-type E3 complex Skp1–Cul1–Skp2
FOXO1	Forkhead box O1
Yap	Yes-associated protein
MTH1	MutT homolog-1
ROS	Oxygen species
IAPs	Inhibitor of apoptosis-related proteins
XIAP	X-linked inhibitor of apoptosis
cIAP1/2	Cellular inhibitor of apoptosis proteins 1 and 2
ML-IAP	Melanoma inhibitor of apoptosis
ILP2	Inhibitor of apoptosis-like protein 2
BIR	Baculoviral IAP repeat
Wwp2	WW domain-containing E3 Ubiquitin protein ligase 2
AIP-2	Atrophin-1-interacting protein 2
PTEN	Phosphatase and tensin homolog
Nedd4-1	Neural precursor cell expressed developmentally downregulated-4-1
FDA	Federal Drug Administration
PROTAC	Proteolysis-targeting chimera
CRBN	Cereblon
mCRPC	Metastatic castration resistant prostate cancer
CRL4CRBN E3 complex	CUL4–DDB1–CRBN–RBX1 E3 complex
GSPT1	G1-to S phase transition 1
EGCG	Epigalocatechin-3-gallate
NSCLC	Non-small-cell lung cancer
I3C	Indole-3-carbinol
HOIP	Hoil-1-interacting protein
EMA	European Medicines Agency