Table 1.

Grading system for strength of recommendation (SoR) and quality of evidence (QoE) as proposed by European Society of Clinical Microbiology and Infectious Diseases (ESCMID) [34]].

Strength of recommendation
A	AGIHO strongly supports a recommendation for use
B	AGIHO moderately supports a recommendation for use
C	AGIHO marginally support a recommendation for use
D	AGIHO supports a recommendation against use
Quality of evidence
I	Evidence from at least one properly designed randomised controlled trial
II∗	Evidence from at least one well-designed clinical trial, without randomisation; from cohort–control or case–control analytic studies (preferably from more than one centre); from multiple time series; or from dramatic results from uncontrolled experiments
III	Evidence from opinion of respected authorities, based on clinical experience, descriptive case studies or report of expert committees
∗Added index for level II
r	Meta-analysis or systematic review of randomised controlled trials
t	Transferred evidence, that is, results from different patients' cohorts or similar immune status situation
h	Comparator group is a historical control
u	Uncontrolled trial
a	Abstract published at an international meeting or manuscript available on preprint server only