PB-020 in combination with MBZ synergistically reduced the viability of CRC cells. (A) HT-29 cells were treated with various concentrations (indicated under the X axis, same below) of PB-020, FBZ and their combination for 72 h, and cell viability was determined using the Cell Counting Kit-8. Bliss independence models were used to analyze the combinatorial inhibitory effect of the combinations. (B) HT-29 cells were treated with various concentrations of PB-020, MBZ and their combination for 72 h, and analyzed as in (A). (C) SW480 cells were treated with various concentrations of PB-020, FBZ and their combination for 72 h, and analyzed as in (A). (D) SW480 cells were treated with various concentrations of PB-020, MBZ and their combination for 72 h, and analyzed as in (A). (E) HCT 116 cells were treated with various concentrations of PB-020, MBZ and their combination for 72 h, and analyzed as in (A). (F) LoVo cells were treated with various concentrations of PB-020, MBZ and their combination for 72 h, and analyzed as in (A). (G) SW620 cells were treated with various concentrations of PB-020, Taxol and their combination for 72 h, and analyzed as in (A).