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. 2022 Nov 23;14(23):5747. doi: 10.3390/cancers14235747

Figure 6.

Figure 6

PB-020 in combination with PD-1 blockade suppressed the transcription of PI3K/AKT pathway genes. (A) The identified DE genes in the PB-020/anti-PD-1 combination group versus control group were largely involved in the PI3K/AKT signaling pathway. (B) Fold change in down-regulated PI3K/AKT pathway genes in the PB-020 group, anti-PD-1 group and PB-020/anti-PD-1 combination group versus the control, respectively. Green arrows indicate synergistic or additive suppression effects. (C) Fold change in up-regulated PI3K/AKT pathway genes in the PB-020 group, anti-PD-1 group and PB-020/anti-PD-1 combination group versus the control, respectively. Red arrows indicate synergistic or additive enhancement effects. (D) Graphical summary of the key findings of this work.