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. 2022 Dec 5;11(23):3929. doi: 10.3390/cells11233929
CCA cholangiocarcinoma
iCCA intrahepatic cholangiocarcinoma
pCCA perihilar cholangiocarcinoma
dCCA distal cholangiocarcinoma
eCCA extrahepatic cholangiocarcinoma
FGFR fibroblast growth factor receptor
FGF fibroblast growth factor
TK tyrosine kinase
TKI tyrosine kinase inhibitor
FDA Food and Drug Administration
IDH1 Isocitrate dehydrogenase 1
ARID1A/ARID1B AT-Rich Interaction Domain 1A/1B
BAP1 BRCA1 Associated Protein 1
TP53 tumour protein p53
RAS rat sarcoma viral proto-oncogene
PTEN Phosphatase And Tensin Homolog
APC Regulator Of WNT Signalling Pathway
EPHA2 Epithelial Cell Receptor Protein Tyrosine Kinase A2
PRKACA/PRKACB Protein Kinase CAMP-Activated Catalytic Subunit Alpha/Beta
ELF3 E74 Like ETS Transcription Factor 3
PD-1/PD-L1 Programmed cell death protein 1/Programmed death-ligand 1
ERBB2 Erb-B2 Receptor Tyrosine Kinase 2
PI3K phosphoinositide 3-kinase
AKT kinases protein kinase B family
mTOR Mammalian target of rapamycin
PLCγ phospholipase C gamma
DAG dystroglycan
PKC protein kinase C
RAF rapidly accelerated fibrosarcoma kinase
MEK Mitogen-activated protein kinase kinase
MAPK Mitogen activated protein kinase
JAK kinase Janus kinase
STAT signal transducer and activator of transcription
IP3 inositol trisphosphate
BICC1 Protein Bicaudal C Homolog 1
PPHLN1 Periphilin 1
TACC3 Transforming Acidic Coiled-Coil Containing Protein 3
MGEA5 meningioma expressed antigen 5
RET Ret Proto-Oncogene
VEGFR1 Vascular endothelial growth factor receptor 1
DDR DNA damage response and repair gene
CDKN2A/B cyclin-dependent kinase inhibitor 2A/B
PBRM1 Polybromo 1 gene
cfDNA cell-free circulating tumour DNA
siRNA small interfering RNA
OS overall survival
DFS disease-free survival
ORR overall response rate
PFS progression-free survival
SD stable disease
PR partial response
PD progressed disease
DCR disease control rate
TEAE treatment-emergent adverse events
AE adverse events