CCA |
cholangiocarcinoma |
iCCA |
intrahepatic cholangiocarcinoma |
pCCA |
perihilar cholangiocarcinoma |
dCCA |
distal cholangiocarcinoma |
eCCA |
extrahepatic cholangiocarcinoma |
FGFR |
fibroblast growth factor receptor |
FGF |
fibroblast growth factor |
TK |
tyrosine kinase |
TKI |
tyrosine kinase inhibitor |
FDA |
Food and Drug Administration |
IDH1 |
Isocitrate dehydrogenase 1 |
ARID1A/ARID1B |
AT-Rich Interaction Domain 1A/1B |
BAP1 BRCA1 |
Associated Protein 1 |
TP53 |
tumour protein p53 |
RAS |
rat sarcoma viral proto-oncogene |
PTEN |
Phosphatase And Tensin Homolog |
APC |
Regulator Of WNT Signalling Pathway |
EPHA2 |
Epithelial Cell Receptor Protein Tyrosine Kinase A2 |
PRKACA/PRKACB |
Protein Kinase CAMP-Activated Catalytic Subunit Alpha/Beta |
ELF3 E74 |
Like ETS Transcription Factor 3 |
PD-1/PD-L1 |
Programmed cell death protein 1/Programmed death-ligand 1 |
ERBB2 |
Erb-B2 Receptor Tyrosine Kinase 2 |
PI3K |
phosphoinositide 3-kinase |
AKT |
kinases protein kinase B family |
mTOR |
Mammalian target of rapamycin |
PLCγ |
phospholipase C gamma |
DAG |
dystroglycan |
PKC |
protein kinase C |
RAF |
rapidly accelerated fibrosarcoma kinase |
MEK |
Mitogen-activated protein kinase kinase |
MAPK |
Mitogen activated protein kinase |
JAK |
kinase Janus kinase |
STAT |
signal transducer and activator of transcription |
IP3 |
inositol trisphosphate |
BICC1 |
Protein Bicaudal C Homolog 1 |
PPHLN1 |
Periphilin 1 |
TACC3 |
Transforming Acidic Coiled-Coil Containing Protein 3 |
MGEA5 |
meningioma expressed antigen 5 |
RET |
Ret Proto-Oncogene |
VEGFR1 |
Vascular endothelial growth factor receptor 1 |
DDR DNA |
damage response and repair gene |
CDKN2A/B |
cyclin-dependent kinase inhibitor 2A/B |
PBRM1 |
Polybromo 1 gene |
cfDNA |
cell-free circulating tumour DNA |
siRNA |
small interfering RNA |
OS |
overall survival |
DFS |
disease-free survival |
ORR |
overall response rate |
PFS |
progression-free survival |
SD |
stable disease |
PR |
partial response |
PD |
progressed disease |
DCR |
disease control rate |
TEAE |
treatment-emergent adverse events |
AE |
adverse events |