Figure 1.

Proposed treatment algorithm for multiple non-metastatic HCC. ⁺ All patients need to be evaluated and discussed in a multidisciplinary team approach, and treatment must be tailored to every specific case. * Laparoscopic approaches should be preferred in centers with adequate expertise and in cirrhotic patients. FLR: future liver remnant; SBRT: stereotactic body radiation therapy; TARE: trans-arterial radio-embolization; TACE: trans-arterial chemo-embolization; HCC: hepatocellular carcinoma.