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. 2022 Dec 5;27(23):8577. doi: 10.3390/molecules27238577

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Scheme 2 — Solid-phase synthesis of 3,4-disubstituted dihydroquinazolin-2(1H)-ones (CA1–CA5). (a) Rink resin was swollen in DMF, 24 h; Fmoc-X-OH, HOBt, DIC, 3 h; (b) Scaffold, HOBt, DIC, 8 h; (c) NH₂-R₂, DIEA, 20 h; (d) Pd(PPh₃)₄, PhSiH₃, DCM, 50 min (2×); (e) CDI, pyridine, DCM, 12 h; (f) 2 M SnCl₂·2H₂O/DMF, 24 h (2×); (g) R₃-COOH, HATU, DIEA, DMAP, overnight; R₃SO₂Cl, DIEA, DCM, overnight; (h) TFA cocktail, 3 h.