Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Dec 5;27(23):8577. doi: 10.3390/molecules27238577

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Scheme 3 — Solid-phase synthesis of 3,4-disubstituted dihydroquinazolin-2(1H)-ones (CA6–CA7). (a) Rink resin was swollen in DMF, 24 h; Scaffold, HOBt, DIC, 8 h; (b) CH₃NH₂·HCl, K₂CO₃, DIEA, 20 h; (c) Pd(PPh₃)₄, PhSiH₃, DCM, 50 min (2×); CDI, pyridine, DCM, 12 h; (d) 2 M SnCl₂·2H₂O/DMF, 24 h (2×); (e) € R₃-COOH, HATU, DIEA, DMAP, overnight; R₃SO₂Cl, DIEA, DCM, overnight; (f) TFA cocktail, 3 h.