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. 2022 Nov 23;27(23):8155. doi: 10.3390/molecules27238155

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Comparative Analysis of EV Proteins between Prostate Cancer Cases and Non-prostate Cancer Controls. To distinguish the EV protein characteristics between prostate cancer cases and non-prostate cancer controls, we compared and identified the upregulated or downregulated EV proteins, then summarized the overlapped EV proteins across three search strategies. (a–c) Volcano plots (Direct-DIA, GPF-DIA, and DDA-DIA, respectively) for statistical differences between the two groups (prostate cancer cases vs. non-prostate cancer controls) were assessed with the Mann-Whitney test. (d) Venn diagram for assessing the overlap of differentiated EV proteins across three search strategies.