Table 6.
Risk assessment levels at 90% sensitivity with corresponding specificity
| Test | Risk assessment tool | Echocardiographic parameter | ||||
|---|---|---|---|---|---|---|
| GLS ≥ -16% |
E/e’ > 14 |
e’ < 8 cm/s |
LAVi > 34 ml/m2 |
LVMi > 88 g/m2 (F) or 102 g/m2 (M) |
||
| Cut point for 90% sensitivity | ARIC-HF (%) | 3 | 5 | 3 | 3 | 4 |
|
WATCH-DM (points) |
8 | 10 | 8 | 8 | 9 | |
| NTpBNP (pg/mL) | 13 | 29 | 13 | 20 | 18 | |
| hs-TnT (pg/mL) | 6 | 6 | 5 | 6 | 6 | |
| AUC | ARIC-HF | 63% | 59% | 54% | 52% | 59% |
| WATCH-DM | 63% | 74% | 60% | 59% | 65% | |
| NTpBNP | 63% | 69% | 55% | 65% | 67% | |
| hs-TnT | 63% | 68% | 61% | 59% | 64% | |
| p-value | 0.948 | < 0.001 | 0.452 | < 0.001 | 0.599 | |
| Specificity at the 90% cut point for sensitivity | ARIC-HF | 11% | 29% | 13% | 12% | 19% |
| WATCH-DM | 12% | 38% | 15% | 12% | 22% | |
| NTpBNP | 10% | 32% | 13% | 23% | 16% | |
| hs-TnT | 20% | 19% | 18% | 22% | 20% | |
| p-value | 0.075 | 0.173 | 0.810 | 0.104 | 0.749 | |
GLS global longitudinal strain, hs-TnT high sensitivity troponin-T, LAVi left atrial volume indexed to body surface area, LVMi left ventricular mass indexed to body surface area, NTpBNP N-terminal pro-brain natriuretic peptide