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. 2022 Nov 29;23(23):14947. doi: 10.3390/ijms232314947

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Detailed morphological changes of mouse meibomian gland (mMG) acini in organotypic slice cultures (OSC) over 21 days. Representative pictures of toluidine blue stained semi-thin sections of mMG OSCs for 21 days (A1–A6). Ultrathin sections analyzed by transmission electron microscopy revealed that basal cells (bc) located next to the basal membrane (bm) enlarge and undergo lipogenesis with increasing cultivation time. Thereby, the bc accumulate more lipids (*) and the nucleus (N) becomes increasingly pyknotic (day 0, day 7 and day 21) (B1–B3). Data are n = 3, Scale bar = 25 µm (A1–A6), 5 µm (B1–B3).