FIG. 3.

Mean changes (±SEM) in the peak elevations of colonic temperature (ΔTco) and FI in rabbits treated with supernatant fluids obtained from PBMC (10⁷ cells/ml) treated at 37°C for 30 min with AIM-V medium (○, n = 5), SEA (1 ng/ml) incubated with control antibody (▴, n = 5), SEA (1 ng/ml) incubated with anti-IL-1β MAb (50 μg/ml) (▵, n = 5), SEA (1 ng/ml) incubated with anti-TNF-α MAb (50 μg/ml) (●, n = 5), SEA (1 ng/ml) incubated with anti-IFN-γ MAb (50 μg/ml) (□, n = 5), or SEA (1 ng/ml) incubated with anti-IL-1β MAb (50 μg/ml) plus anti-TNF-α MAb (50 μg/ml) plus anti-IFN-γ MAb (50 μg/ml) (■, n = 5). The supernatant fluids (1.2 ml/kg) were administered i.v. into rabbits. ∗, Significantly different from corresponding control values (SEA-treated PBMC incubated control antibody group) (P < 0.05; ANOVA).