Table 1.

The role of sirtuins in gastric cancer.

Name	Function	References
SIRT1	inhibits GC cell proliferation and tumor growth; GC growth and metastasis by FOXO1 and YAP signaling; participates in mitophagy; deacetylation of histone substrates, transcription factors and cofactors (p53, STAT3, DBC1, FOXO, c-Myc & Ku70); RSV prevents STAT3 and NF-κB activation;	[64,67,74,75,76,77]
SIRT2	influences the migration and invasion of GC cells to metastatic niche;	[62]
SIRT3	inhibition of NOTCH1 expression; blocking SIRT3 expression promoted cell division and tumor growth; decreased HIF-1α and ROS production; promoting proliferation, glucose uptake, MnSOD activity;	[78,79,80,81]
SIRT4	inhibiting cell proliferation, migration, and invasion; reduces the number of colonies formed by GC cells; stops the cell cycle in the G1 phase;	[65,82]
SIRT5	promotes autophagy; reduces the number of colonies and the viability of GC cells;	[83]
SIRT6	inhibits cell viability, proliferation, colony formation, and cell cycle; increases apoptosis; inhibits the JAK2/STAT3 pathway;	[84]
SIRT7	promotes GC cells proliferation and growth; cell survival and migration; inhibits apoptosis;	[30,63]