Table 2.

The role of sirtuins in GC and known factors regulating their activity.

Name	Modulated By
SIRT1	natural: resveratrol, quercetin, apigenin, catechin, epicatechin, theobromine, curcumin, soy isoflavones, sulforaphane, olivetol, isothiocyanates, piceatannol, cinnamon;
	synthetic: S17834, SRT1720;
SIRT2	synthetic: tempol, (SOD1), 1,4-DHP derivative;
SIRT3	natural: resveratrol, epicatechin, curcumin, piceatannol;
	synthetic: acetyl-CPS1,1,4-DHP derivative;
SIRT4	natural: resveratrol, curcumin;
	synthetic: DMS-CPS, HMG-CPS1, acetyl-CPS1;
SIRT5	snatural: piceatannol;
	synthetic: succinyl peptide, DMS-CPS, HMG-CPS1, UBCS039;
SIRT6	natural: iso-quercetin, luteolin, and cyanidin;
	synthetic: tempol, copper-zinc superoxide dismutase (SOD1) mimetic, pyrrole (1,2a) quinoxaline derivative, UBCS039;