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. 2022 Nov 30;27(23):8343. doi: 10.3390/molecules27238343

Figure 5.

Figure 5

Assessment of cytokine production by peritoneal macrophages treated with SintMed149 or SintMed150. Mouse peritoneal exudate macrophages stimulated or not with LPS + IFN-γ were cultured in the absence or presence of SintMed149 (A,C) or SintMed150 (B,D) (10, 20, and 40 µM) or dexamethasone (Dexa; 10 µM). Cell-free supernatants were collected after 4 h for TNFα quantification (A and B) or 24 h for IL-6 quantification (C and D). “-” refers to the group of untreated and unstimulated cells. C- refers to the group of untreated cells stimulated with LPS + IFNγ. Values represent the mean (±standard deviation) of four determinations obtained in one of three experiments performed. *** p < 0.001 compared to stimulated and untreated cells; ** p < 0.01 compared to stimulated and untreated cells; # p < 0.05 compared to unstimulated and untreated cells; $ p < 0.05 compared to dexamethasone-treated cells.