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. 2022 Nov 30;27(23):8343. doi: 10.3390/molecules27238343

Figure 6.

Figure 6

Assessment of cytokine production by splenocytes treated with SintMed149 and SintMed150. The concentrations of IL-2 (A,B), IL-4 (C,D), and IFN-γ (E,F) were determined in cell-free supernatants from splenocyte cultures stimulated with concanavalin A (Con A, 5 µg/mL) and treated or not with SintMed149 and SintMed150 (10, 20, 40 μM) or dexamethasone (10 μM) for 24 h. Culture supernatants were collected and cytokine quantification was performed by ELISA. Values represent the mean (±standard deviation) of four determinations obtained in one of three experiments performed. *** p < 0.001 compared to untreated and Con A-stimulated cultures ** p < 0.01 in comparison to untreated and Con A-stimulated cultures * p < 0.05 compared to untreated and Con A-stimulated cultures. # p < 0.05 compared to untreated and unstimulated cultures with Con A. $ p < 0.05 compared to dexamethasone-treated and stimulated cultures.