3β-HSD |
3β-hydroxy-D5-C27-steroid dehydroxylase |
6-ECDCA |
6a-ethyl-chenodeoxycholic acid |
ACC2 |
Acetyl CoA carboxylase |
AGRP |
Agouti-related peptide |
AKR1C4 |
3a-hydroxysteroid dehydrogenase |
AKR1D1 |
D4-3-oxosteroid 5b-reductase |
AKT |
Protein kinase B |
ALT |
Alanine aminotransferase |
AMPs |
Antimicrobial peptides |
ASBT |
Apical sodium-dependent bile salt transporter |
BA |
Bile acids |
BAAT |
Bile acid-CoA:amino acid N-acyltransferase |
BACS |
Bile acid CoA synthase |
ABCB11 |
Bile acid export pump |
BAT |
Brown adipose tissue |
BSEP |
Bile salt export pump |
BSH |
Bile salt hydrolase |
C4 |
7a-hydroxy-4-cholesten-3-one |
CA |
Cholic acid |
CCK |
Cholecystokinin |
CCl4 |
Carbon tetrachloride |
CDCA |
Chenodeoxycholic acid |
CF |
Cycling frequency |
COX-2 |
Cylcooxygenase-2 |
CREB |
cAMP regulatory element binding protein |
CYP7A1 |
Cholesterol-7α-hydroxylase |
CYP27A1 |
Cytochrome P450 27A1 |
CYP2A12 |
Cytochrome P450 2A12 |
CYP2C70 |
Cytochrome P450 2C70 |
CYP7A1 |
Cytochrome P450 7A1 |
CYP7B1 |
Cytochrome P450 7B1 |
CYP8B1 |
Cytochrome P450 8B1 |
DBD |
DNA binding domain |
DCA |
Deoxycholic acid |
eIF4B |
Eukaryotic initiation factor 4B |
eIF4E |
Eukaryotic initiation factor 4E |
ER2 |
Everted hexanucleotide repeat separated by 2 nucleotides |
ERK |
Extracellular-signal-regulated protein kinase |
FAR |
Fractional absorption rate |
FFA |
Free fatty acid |
FGF |
Fibroblast growth factor |
FGF15 |
Fibroblast growth factor 15 |
FGF19 |
Fibroblast growth factor 19 |
FGFR |
Fibroblast growth factor receptor |
FGFR1 |
Fibroblast growth factor receptor 1 |
FGFR4 |
Fibroblast growth factor receptor 4 |
FLINT |
Farnesoid X receptor ligand obeticholic acid in NASH treatment |
FXR |
Farnesoid X receptor |
FXRE |
Farnesoid X receptor response element |
FTR |
Fractional turnover rate |
GGT |
Gamma-glutamyltransferase |
GLP-1 |
Glucagon-like peptide 1 |
GLUT2 |
Glucose transporter 2 |
GPBAR-1 |
G-protein-coupled bile acid receptor-1 |
GS |
Glycogen synthase |
GSK3a |
Glycogen synthase kinase 3a |
HREs |
Hormone response elements |
HSC |
Hepatic stellate cell |
IkB |
Inhibitor of nuclear factor kappa B |
IBABP |
Intestinal bile acid binding protein |
IFN-g |
Interferon-gamma |
iNOS |
Inducible nitric oxide synthase |
IR1 |
Inverted hexanucleotide repeat separated by 1 nucleotide |
KO |
Knockout |
LBD |
Ligand-binding domain |
LCA |
Lithocholic acid |
LRH-1 |
Liver receptor homologue 1 |
LPS |
Lipopolysaccharide |
JNK |
JUN N-terminal kinase |
JUN |
Jun proto-oncogene |
MAGs |
Metagenome-assembled genomes |
MCA |
Muricholic acid |
MCD |
Methionine-choline deficient |
MCP-1 |
Monocyte chemoattractant protein-1 |
MRP2 |
Multidrug resistance-associated protein 2 |
mTOR |
Mammalian target of rapamycin |
NAFLD |
Non-alcoholic fatty liver disease |
NASH |
Non-alcoholic steatohepatitis |
NF-kB |
Nuclear factor kappa-light chain enhancer of activated B cell |
NPY |
Neuropeptide Y |
NR s |
Nuclear receptors |
NLRP3 |
NACHT LRR and PYD domains-containing protein 3 |
NTCP |
Sodium taurocholate co-transporting polypeptide |
OATP |
Organic anion transporting polypeptide |
OCA |
Obeticholic acid |
OSTα |
Organic solute transporter alpha |
OSTb |
Organic solute transporter beta |
P90RSK |
p90 ribosomal S6 kinase |
PBC |
Primary biliary cirrhosis |
PEPCK |
Phosphoenolpyruvate carboxykinase |
PFIC |
Progressive familial intrahepatic cholestasis |
PGC-1α |
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha |
PGC-1b |
Peroxisome proliferator-activated receptor gamma coactivator 1-beta |
PPARγ |
Peroxisomal proliferator activated receptor gamma |
PXR |
Pregnane X receptor |
RCT |
Reverse cholesterol transport |
RXR |
Retinoid X receptor |
S1PR2 |
Sphingosine-1-phosphate receptor 2 |
S6K1 |
S6 kinase beta-1 |
SCD1 |
Stearoyl-CoA desaturase 1 |
SIBO |
Small intestinal bacterial overgrowth |
SHP |
Small heterodimer partner |
SREBP1c |
Sterol regulatory element-binding protein 1c |
STAT3 |
Signal transducer and activator of transcription 3 |
SULT2A1 |
Sulfotransferase 2A1 |
TCA |
Taurocholic acid |
TDCA |
Taurodeoxycholic acid |
TGR5 |
Takeda G-protein receptor 5 |
TLCA |
Taurolithocholic acid |
TNFα |
Tumor necrosis factor alpha |
VDR |
Vitamin D receptor |
VLDL |
Very low-density lipoprotein |
WAT |
White adipose tissue |