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. 2022 Dec 6;11(23):3939. doi: 10.3390/cells11233939

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of phytocannabinoids on mRNA levels of genes involved in extracellular matrix maintenance in CCD-1064Sk human dermal fibroblasts. mRNA levels were presented as a ratio of the target gene relative to GAPDH for expression of (A) COL1A1, (B) COL3A1, (C) ELN, (D) HAS1, (E) MMP1, (F) MMP2, and (G) TIMP1. Data were analyzed with an ANOVA test followed by a Dunnett’s post-hoc multiple comparison test compared to the vehicle. Bars represent mean ± SEM, n = 3. Significance is indicated using the following scale: * p < 0.05, ** p < 0.01, *** p < 0.001. CBD, cannabidiol; DMSO, dimethyl sulfoxide (vehicle); THC, delta-9-tetrahydrocannabinol.