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. 2022 Dec 6;11(23):3939. doi: 10.3390/cells11233939

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of phytocannabinoids on mRNA levels of metabolic regulators in CCD-1064 human dermal fibroblasts. mRNA levels were presented as a ratio of the target gene relative to GAPDH for expression of (A) SIRT1, (B) SIRT3, (C) SIRT4, and (D) SIRT6. Data were analyzed with an ANOVA test followed by a Dunnett’s post-hoc multiple comparison test compared to the vehicle. Bars represent mean ± SEM, n = 3. CBD, cannabidiol; DMSO, dimethyl sulfoxide (vehicle); THC, delta-9-tetrahydrocannabinol. The asterisk shows significant difference (p < 0.05).