Figure 11.

Effects of phytocannabinoids on cannabinoid receptors and metabolic regulators in CCD-1064 human dermal fibroblasts (PDL 24). Relative densitometry was presented as a ratio of the target protein relative to GAPDH for expression of (A) CB1, (B) CB2, (C) SIRT1, and (D) EGFR, (E) representative images blots with each protein detected. Original membranes can be seen in Figures S21–S25. Data were analyzed with an ANOVA test followed by Tukey’s post-hoc multiple comparison test. Bars represent mean ± SEM, n = 3. Significance is indicated using the following scale: * p < 0.05, ** p < 0.01. CBD, cannabidiol; DMSO, dimethyl sulfoxide (vehicle); THC, delta-9-tetrahydrocannabinol.