Figure 5.
Circulating levels of MCP-1 (A) in male offspring of dams treated with CCX or vehicle during lactation. The expression levels of inflammatory response-related genes in EWAT (B) are also depicted for the CAF-fed progeny. Data are the mean ± SEM (n = 11–13). DxP: the interaction between diet and metabolic programming effect of CCX (two-way ANOVA, p < 0.05). $ The effect of diet within vehicle groups (Student’s t test, p < 0.05); * metabolic programming effect of CCX within CAF groups (Student’s t test, p < 0.05). STD, chow diet; veh, vehicle; CCX, cocoanox extract; CAF, cafeteria diet; MCP-1, monocyte chemoattractant protein-1; EWAT, epididymal white adipose tissue; Tnfα, tumor necrosis factor; Emr1, EGF-like module containing, mucin-like, hormone receptor-like 1; Il10, interleukin 10; iNos, nitric oxide synthase 2, inducible; Cd74, major histocompatibility complex, class II invariant chain; Mgl1, C-type lectin domain family 10, member A; Mrc1, mannose receptor, C type 1.