Table 2.

Fertility preservation options for BC patients prior to and during anticancer treatment.

Technique	Procedure	Risk Related with Procedure	Ref.
COS and cryopreservation of oocyte	Ovarian stimulation with estrogen, oocyte pick up and egg banking.	Exposition to estrogen during the induction	[112]
	Required approximately 2–4 weeks prior to starting any cancer treatment	Ovarian hyperstimulation syndrome	[113]
COS and cryopreservation of embryos	Ovarian stimulation with estrogen, oocyte pick up, in vitro fertilization (requests a sperm donor) and embryo banking.	Exposition to estrogen during the induction	[112]
	Required approximately 2–4 weeks prior to starting any cancer treatment	Ovarian hyperstimulation syndrome	[113]
Ovarian tissue cryopreservation	Ovarian tissue surgically removed, cryopreserved and reimplanted after cancer treatment	Performed only in selected centers	[112]
	No daley in starting cancer treatment	Requires surgery	[113]
GnRHa administration	Hormonal treatment administrated during the full duration of anticancer treatment	Controvertial and debated role	[114]

Abbreviations: COS: controlled ovarian stimulation; GnRHa: gonadotropin-releasing hormone agonists.