Table 2.
S.No | KD Beneficial | KD Contraindications |
---|---|---|
1 | Adenylosuccinate lyase deficiency64 | Carnitine deficiency (primary) |
2 | CDKL5 encephalopathy | Carnitine palmitoyltransferase (CPT) I or II deficiency |
3 | Childhood absence epilepsy | Carnitine translocase deficiency |
4 | Cortical malformations | β-oxidation defects |
5 | Epilepsy of infancy with migrating focal seizures | Medium-chain acyl dehydrogenase deficiency (MCAD) |
6 | Epileptic encephalopathy with continuous spike-and-wave during sleep | Long-chain acyl dehydrogenase deficiency (LCAD) |
7 | Glycogenosis type V | Short-chain acyl dehydrogenase deficiency (SCAD) |
8 | Juvenile myoclonic epilepsy | Long-chain 3-hydroxyacyl-CoA deficiency |
9 | Lafora body disease | Medium-chain 3-hydroxyacyl-CoA deficiency. |
10 | Landau-Kleffner syndrome | Pyruvate carboxylase deficiency |
11 | Lennox-Gastaut syndrome | Porphyria |
12 | Phosphofructokinase deficiency | Inability to maintain adequate nutrition |
13 | Rett syndrome | Surgical focus identified by neuroimaging and video-EEG monitoring |
14 | Subacute sclerosing panencephalitis (SSPE) | Parent or caregiver noncompliance |
Note: Data has been taken from Kossoff et al., 2018 [64].