Table 1.
Patient Characteristics.
| Patient Demographics | Univariable Analysis | |||||
|---|---|---|---|---|---|---|
| OS | PFS | |||||
| Parameter | Categories | Number (%), n = 46 (100%) | HR (95% CI) | p-Value | HR (95%CI) | p-Value |
| Age (years) | Median (IQR) | 61.8 (20.0) | 1.0 (0.9, 1.0) | 0.33 | 1.0 (1.00, 1.02) | 0.89 |
| Sex | Male | 26 (56.5) | 0.7 (0.4, 1.4) | 0.35 | 0.8 (0.4, 1.5) | 0.46 |
| Female | 20 (43.5) | |||||
| ECOG Performance Status | 0 | 33 (71.7) | 1.9 (0.9, 3.8) | 0.073 | 1.9 (1.0, 3.7) | 0.076 |
| 1 | 11 (23.9) | |||||
| 2 | 1 (2.2) | |||||
| 3 | 1 (2.2) | |||||
| 4 | 0 (0) | |||||
| Sites of Metastasis at Baseline | Liver | 41 (89.1) | 2.0 (0.6. 6.6) | 0.25 | 1.3 (0.5, 3.6) | 0.65 |
| Lung | 21 (47.5) | 1.1 (0.6, 2.1) | 0.8 | 0.9 (0.5, 1.7) | 0.8 | |
| Brain | 3 (6.5) | 1.0 (0.3, 3.5) | 0.95 | 0.7 (0.2, 2.4) | 0.62 | |
| Bone | 11 (23.9) | 1.2 (0.6, 2.5) | 0.6 | 1.3 (0.7, 2.6) | 0.48 | |
| LN | 14 (30.4) | 2.1 (1.1, 4.2) | 0.031 | 1.5 (0.8, 2.8) | 0.24 | |
| Other | 20 (43.5) | 0.6 (0.3, 1.2) | 0.13 | 0.7 (0.4, 1.3) | 0.26 | |
| Liver Only | 14 (30.4) | |||||
| Liver + Extrahepatic. (vs. Liver Only) | 28 (60.9) | 1.4 (0.6, 3.2) | 0.38 | 0.8 (0.4, 1.5) | 0.48 | |
| Extrahepatic Only. (vs. Liver Only) | 4 (8.7) | 0.5 (0.1, 2.3) | 0.36 | 0.7 (0.2, 2.6) | 0.63 | |