Table 2.
The table of advantages and disadvantages of various antidepressant treatments.
| Antidepressants | Advantages | Disadvantages |
|---|---|---|
| SSRIs | GAD, fibromyalgia | Sexual dysfunction, nausea, vomiting, insomnia, serotonin syndrome, HTN |
| SNRIs | GAD, fibromyalgia | Sexual side effects, insomnia, nausea, vomiting, HTN, serotonin syndrome |
| NDRIs | Alcohol, smoking cessation, no sexual dysfunction, no weight gain | Anxiety, suicidal ideation, seizures, general side effects |
| MAOIs | Effectiveness for atypical depression, PTSD | Low sex drive, weight gain, high or low blood pressure, keep off during alcoholism, kidney and heart disease, food restriction |
| TCA | Proven efficacy, low cost | Urinary retention, xerostomia, tachycardia, VF, SCD |
| Ketamine | Severe, treatment-resistant depression, increasing libido | Numbness, tingling, dizziness, transient cognitive deficits, and increasing blood pressure |
| Memantine | Moderate and severe form depression, highly tolerated by many patients, improving cognition and general quality of life | Constipation, nausea, weight gain, diarrhea, confusion, sleeplessness, shortness of breath, and hallucination |
| D-cycloserine | Well tolerated, do not produce psychotomimetic effects | Dizziness, hyperexcitability, anxiety, memory loss, and gastrointestinal problems |
| Magnesium | Anxiety, anticonvulsive effect | Muscle weakness, lethargy, nausea, diarrhea, and a fall in blood pressure |
| Riluzole | Anticonvulsive effect | Fatigue, nausea, and weight loss |
| Mirtazapine | Can be used as a preventive treatment for PSD | Increased appetite, weight gain, headache, nausea or vomiting, diarrhea, and constipation |
| Agomelatine | Short-term and long-term efficacy in treating PSD | Hepatic impairment, anxiety, nausea and vomiting, stomach pain, insomnia, dizziness, fatigue, and an increase in weight |