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Effects of the screened compounds on isolated SIRT1 enzyme activity. SIRT1 activity is expressed as % of the effect promoted by the reference compound resveratrol (Resv) 100 µM. The sirtuin inhibitor sirtinol (Sirt) 10 µM was used as a negative control. Results are shown as mean ± SEM. * indicates significant difference vs. vehicle (*** p < 0.001).
