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. 2022 Nov 22;23(23):14518. doi: 10.3390/ijms232314518

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Inflammasome, innate immune and redox element gene expression in critically ill COVID-19 tracheal biopsies. Tracheal biopsies were obtained from invasive ventilated critically ill patients without COVID-19 and no respiratory disease/infections (control, n = 32), SARS-CoV-2 B.1 variant (n = 31), and B.1.1.7 VOC alpha variant (n = 20). Total mRNA was extracted and quantified by RT-qPCR to analyze the expression of inflammasome genes IL-1β, IL-18, NLRP3, ASC, CASP1, innate immune genes TLR2, MyD88, and redox Nrf2 and NOX4 genes. Data are presented as scatter dot blots with median and interquartile range values. p-values are based on the Kruskal-Wallis test and Dunn’s post hoc test for multiple comparisons.