Figure 5.

SARS-CoV-2 mosaic (S-E-M) recombinant protein mediates inflammatory responses through toll-like receptor 2 (TLR2). (A) Differentiated U937 macrophages and (B) bronchial epithelial cells BEAS2B were transiently transfected with control siRNA(-) or siRNA-TLR2 and stimulated with vehicle (control) or mosaic (S-E-M) for 24 h. Data are presented as scatter dot blot of n = 4 independent experiments run in triplicate, with median and interquartile range values. Statistical analysis was carried out using by Kruskal-Wallis test and Dunn’s post hoc test for multiple comparisons. * p < 0.05 vs. control.