Figure 6.

SARS-CoV-2 mosaic (S-E-M) recombinant protein mediates inflammasome and redox expression through toll-like receptor 2 (TLR2) in differentiated U937 macrophages. Differentiated U937 macrophages were transiently transfected with control siRNA(-) or siRNA-TLR2 and stimulated with vehicle (control) or mosaic (S-E-M) for 24 h. mRNA expression of target genes was measured by RT-qPCR. Data are presented as scatter dot blot of n = 4 independent experiments run in triplicate, with median and interquartile range values. Statistical analysis was carried out using by Kruskal-Wallis test and Dunn’s post hoc test for multiple comparisons. * p < 0.05 vs. control.