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. 2022 Dec 2;14(23):5976. doi: 10.3390/cancers14235976

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Mechanism of scabertopine inhibiting invasion and promoting necroptosis in human bladder cancer J82 cells. Scabertopin can reduce mitochondrial membrane potential and stimulate mitochondrial ROS production, thereby activating RIP1/RIP3/MLKL phosphorylation, mediating J82 cell necroptosis, and inhibiting the FAK/PI3K/Akt/MMP-9 signaling pathway. This in turn inhibits the migration and invasive potential of J82 cells. Akt: Akt-protein kinase B; FAK: focal adhesion kinase; MLKL: mixed lineage kinase like; MMP-9: matrix metalloprotease 9; NAC: N-acetylcysteine; PI3K: phosphoinositide 3-kinase; p-: phosphorylated; RIP: receptor-interacting protein.