Figure 1.

IL-6 levels are associated with tumor immunity in clear cell renal cell carcinoma. The correlations between IL-6 levels and immune cells or stromal cells were analyzed using clear cell RCC datasets (n = 533) from The Cancer Genome Atlas. (a) Correlation plots of IL-6 levels with anticancer immune cells: CD8+ T cells, CD4+ T cells, dendritic cells, and natural killer cells. (b) Correlation plots of IL-6 levels with regulatory T cells, myeloid-derived suppressor cells, monocytes, and cancer-associated fibroblasts were generated using Pearson’s correlation. The blue solid lines represent the regression curve, and the shaded areas represent the 95% confidence interval bands of the best fit. TIDE, tumor immune dysfunction, and exclusion.