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. 2022 Dec 3;14(23):5985. doi: 10.3390/cancers14235985

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Baseline serum IL-6 levels and survival outcome with pembrolizumab/axitinib therapy. IL-6 > 6.5 pg/mL was defined as IL-6 High. (a) Kaplan–Meier curves showing PFS according to IL-6 level. (b) Kaplan–Meier curves showing OS according to IL-6 level. (c) Forest plots showing PFS according to nephrectomy, metastasis, pathology, Eastern Cooperative Oncology Group (ECOG) performance status, International Metastatic Renal Cell Carcinoma Data Consortium (IMDC) risk criteria, and IL-6 status. (d) Forest plots showing OS according to nephrectomy, metastasis, pathology, ECOG performance status, IMDC risk criteria, and IL-6 status. Hazard ratios and 95% confidence intervals are shown in survival curves and forest plots. Multivariate analyses were conducted using Cox proportional hazard regression. PFS, progression-free survival; OS, overall survival.