Table 1.
Characteristics of the healthy subjects (controls, n = 40) and patients with diarrhea predominant irritable bowel syndrome (IBS-D, n = 40) included in the study, and the selected laboratory baseline data, tryptophan intake, and severity symptoms; mean (SD).
| Feature 1 | Controls-Mean (SD) | Patients-Mean (SD) | p-Value |
|---|---|---|---|
| Age (years) | 44.2 (7.6) | 45.9 (9.3) | p > 0.05 |
| Gender (M/F) | 17/23 (42.5/57.5%) | 14/26 (35.0/65.0%) | p > 0.05 |
| BMI (kg/m2) | 23.9 (1.8) | 22.6 (2.1) | p > 0.05 |
| CRP (mg/L) | 1.48 (0.3) | 6.5 (2.9) | p = 0.038 |
| FC (µg/g) | 24.3 (6.2) | 45.4 (19.5) | p = 0.048 |
| AST (U/L) | 16.1 (3.2) | 17.3 (9.5) | p > 0.05 |
| ALT (U/L) | 17.3 (4.8) | 22.1 (7.9) | p > 0.05 |
| Amylase (U/L) | 36.8 (13.1) | 43.2 (21.9) | p > 0.05 |
| Lipase (U/L) | 73.4 (21.3) | 48.3 (16.6) | p > 0.05 |
| Creatinine (mg/dL) | 0.74 (0.2) | 0.88 (0.2) | p > 0.05 |
| GFR (mL/min) | 96.5 (10.7) | 89.5 (11.1) | p > 0.05 |
| TRP (mg daily) | 1269 (191) | 1324 (223) | p > 0.05 |
| TRP (mg/kg) | 21.8 (3.8) | 23.2 (4.1) | p > 0.05 |
| HAM-A | 7.85 (1.2) | 21.3 (4.7) | p = 0.00002 |
| HAM-D | 8.56 (2.6) | 14.4 (2.01) | p = 0.004 |
| ISI | 14.5 (1.6) | 9.12 (3) | p = 0.00003 |
1 average (SD, standard deviation), BMI—body mass index, CRP—C-reactive protein, FC—fecal calprotectin, AST—aspartate aminotransferase, ALT—alanine aminotransferase, GFR—glomerular filtration rate, and TRP—tryptophan intake.