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Components of the serotonin pathway in healthy subjects (Controls) and in patients with diarrhea—predominant irritable bowel syndrome (IBS-D).
| Compound | Controls-Mean (SD) | IBS-D-Mean (SD) | p-Value |
|---|---|---|---|
| SER (ng/mL) | 142.3 (36.4) | 198.2 (38.1) | p = 0.0009 |
| MEL (pg/mL) | 9.4 (2.4) | 8.6 (1.2) | p > 0.05 |
| 5-HIAA (mg/24 h) | 6.0 (1.7) | 7.7 (1.5) | p = 0.0004 |
| aMT6s (µg/24 h) | 11.2 (4.3) | 10.6 (2.4) | p > 0.05 |
SER–serotonin, MEL—melatonin, 5-HIAA—5-hydroxyindoleacetic acid, and aMT6s—6-sulfatoxymelatonin.
