Table 4.
Compounds of the serotonin pathway and severity symptoms in patients with IBS-D before and after nutritional treatment.
| Feature | Before-Mean (SD) | After-Mean (SD) | p-Value |
|---|---|---|---|
| SER (ng/mL) | 198.2 (38.1) | 123.2 (24.6) | p = 0.00002 |
| MEL (pg/mL) | 8.6 (1.2) | 7.8 (1.9) | p > 0.05 |
| 5-HIAA (mg/24 h) | 7.7 (1.5) | 5.5 (0.8) | p = 0.00007 |
| aMT6s (µg/24 h) | 10.6 (2.4) | 10.5 (1.9) | p > 0.05 |
| GSRS (points) | 21.8 (2.9) | 9.7 (2.5) | p = 0.00002 |
| HAM-A (points) | 19.3 (4.7) | 14.9 (3.4) | p = 0.00002 |
| HAM-D (points) | 14.4 (2.1) | 12.9 (3.2) | p > 0.05 |
| ISI (points) | 14.5 (1.6) | 13.8 (1.5) | p > 0.05 |
GSRS—gastrointestinal symptom rating scale, HAM-A—Hamilton anxiety rating scale, HAM-D—Hamilton depression rating scale, and ISI—insomnia severity scale.