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. 2022 Nov 30;23(23):15040. doi: 10.3390/ijms232315040

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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B4GALT1 expression in lung fibrosis and lung cancer (×20 magnification). (a) An example of near-normal lung tissue is shown (B4GALT1 staining); (b) positive staining in lung cancer; (c) tumor (on the left) and UIP (on the right) of the same patient show simultaneous strong cytoplasm B4GALT1 expression; (d) strong B4GALT1 expression is observed in most fibroblastic foci in UIP both in connective tissue and alveolar epithelium; (e) and possibly in UIP fibrous reactive remodeling of lung tissue not related to IPF; (f) quantification of grading expression of B4GALT1; (g) there are B4GALT1-positive immune lymphocyte infiltrating cells in neoplastic and UIP tissue samples; and (h,i) capillary endothelium expressing B4GALT1 was observed, in the same patient, both in the immediately peritumoral connective tissue area and adjacent to the UIP pattern fibrous.

B4GALT1 expression in lung fibrosis and lung cancer (×20 magnification). (a) An example of near-normal lung tissue is shown (B4GALT1 staining); (b) positive staining in lung cancer; (c) tumor (on the left) and UIP (on the right) of the same patient show simultaneous strong cytoplasm B4GALT1 expression; (d) strong B4GALT1 expression is observed in most fibroblastic foci in UIP both in connective tissue and alveolar epithelium; (e) and possibly in UIP fibrous reactive remodeling of lung tissue not related to IPF; (f) quantification of grading expression of B4GALT1; (g) there are B4GALT1-positive immune lymphocyte infiltrating cells in neoplastic and UIP tissue samples; and (h,i) capillary endothelium expressing B4GALT1 was observed, in the same patient, both in the immediately peritumoral connective tissue area and adjacent to the UIP pattern fibrous.