FIG. 2.

Time course of the histology of pouch walls from control (upper panels) and Rhodococcus sp. strain 4306 TDM-treated (lower panels) mice at 3, 7, 14, and 28 days after injection of either FIA alone or 300 μg of TDM in FIA, respectively. While control pouches showed no appreciable increase in the thickness of granulomatous tissue (as indicated by arrowed bars) during experimental periods, TDM-treated pouches significantly increased in thickness at day 7 and then decreased at day 14. Various sizes of oil droplets (arrowheads) were localized in the necrotic tissue and granulomatous tissue. M, dermal muscular layer; N, necrotic tissue. Images were H&E stained. Bar, 200 μm.