Table 3.
Histologic features of patients with crescentic IgA nephropathy according to the presence or absence of ANCAs.
| N = 17 | ANCA-Positive N = 5 (3 IgA/2 IgG) |
ANCA-Negative N = 12 |
p-Value | |
|---|---|---|---|---|
| Glomerular | ||||
| Global glomerulosclerosis (%) | 248 | 18.2 | 27.5 | NS |
| Segmental glomerulosclerosis (%) | 11 | 7.2 | 12.6 | NS |
| Mesangial hypercellularity (%) | 82 | 60 | 90 | NS |
| Nº of crescents | ||||
| Crescents 0–25% | 11 (64%) | 0 | 11 (91%) | 0.04 |
| Crescents 26–50% | 5 (29%) | 4 (80%) | 1 (8%) | NS |
| Crescents 51% o > | 1 (6%) | 1 (20%) | 0 | NS |
| Fibrinoid necrosis | 5 (30%) | 4 (80%) | 1 (8%) | 0.01 |
| Tubule-Interstice | ||||
| Interstitial fibrosis/tubular atrophy | ||||
| Mild (<25%) | 8 (47%) | 3 (60%) | 5 (40%) | 0.04 |
| Moderate (26–50%) | 6 (35%) | 1 (20%) | 5 (40%) | NS |
| Severe (>50%) | 3 (17.6%) | 1 (20%) | 2 (17%) | 0.07 |
| IgA staining (%) | ||||
| + | 41.1 | 40 | 41.6 | NA |
| ++ | 13.8 | 40 | 16.6 | |
| +++ | 35.3 | 20 | 41.6 |
NS—not significant, NA—does not apply, + for mild, ++ for moderate, and +++ for strong.