Figure 4.

The cell based or platelet-driven model of hemostasis reflects the incorporation of platelets and other components of primary hemostasis (e.g., plasma and platelet derived VWF) and the secondary elements of hemostasis (i.e., clotting factors) to provide a composite hemostasis process. Platelets provide both the building blocks to the formation of the platelet plug (or thrombus) as well as the assembly point for secondary hemostasis pathways. Platelets contain various granules which release their cargo upon platelet activation; this cargo comprises procoagulant material such as factor V, fibrinogen, and VWF.