Figure 7.
Negatively stained TEM micrographs of (A–D) C-TERb and (E–H) C-TERa incubated for 144 h (6 days) in TBS at ~20 °C (CC-TER = 10 µM). The two C-TER isoforms show a similar morphologic diversity. (A,E) Long single straight (SSFs) (indicated by the white arrows) and double straight fibrils (DSFs) (indicated by the black arrows). (B,F) Such SSFs and DSFs tend also to densely pack into multiple straight fibrils (MSFs). (C,G) SSFs (indicated by the white arrows) can be found in extended and diffuse networks of intersecting filaments. (D,H) Amorphous aggregates are also observed. The scale bar is provided at the bottom right of each TEM micrograph.