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. 2022 Nov 26;23(23):14782. doi: 10.3390/ijms232314782

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Hypothalamic and pituitary effects of disruptor treatment. Male THAI mice treated orally for 6 days with 150 mg/bwkg/day of TBBPA in corn oil containing 2% Et-OH or for 5 days with 10 mg/bwkg/day of diclazuril as a saline suspension; thyroid hormone action quantified with luciferase mRNA levels; (A–D) TBBPA; (E–H) diclazuril; (A) PVN trh mRNA after TBBPA; (B) pituitary tshb mRNA after TBBPA; (C) ARC-ME luciferase mRNA after TBBPA; (D) pituitary luciferase mRNA after TBBPA; (E) PVN trh mRNA after diclazuril; (F) pituitary tshb mRNA after diclazuril; (G) ARC-ME luciferase mRNA after diclazuril; (H) pituitary luciferase mRNA after diclazuril. n = 4–6 mice/group; figure shows Tukey Box Plots, α = 0.05.

Hypothalamic and pituitary effects of disruptor treatment. Male THAI mice treated orally for 6 days with 150 mg/bwkg/day of TBBPA in corn oil containing 2% Et-OH or for 5 days with 10 mg/bwkg/day of diclazuril as a saline suspension; thyroid hormone action quantified with luciferase mRNA levels; (A–D) TBBPA; (E–H) diclazuril; (A) PVN trh mRNA after TBBPA; (B) pituitary tshb mRNA after TBBPA; (C) ARC-ME luciferase mRNA after TBBPA; (D) pituitary luciferase mRNA after TBBPA; (E) PVN trh mRNA after diclazuril; (F) pituitary tshb mRNA after diclazuril; (G) ARC-ME luciferase mRNA after diclazuril; (H) pituitary luciferase mRNA after diclazuril. n = 4–6 mice/group; figure shows Tukey Box Plots, α = 0.05.